Black water fly has a weak antithrombin effect in vitro, and has the effect of activating the fibrinolytic system in vitro and in vivo.
Aqueous flies 540mg/(kg/d) and 270mg/(kg/d) gastric lavages for 7 cONsecutive days can significantly prolong the bleeding time of rats and significantly reduce plasma fibrinogen content; the maximum aggregation rate of platelets in the high-dose group also has a significant inhibiTOry effect. 560mg (raw drug) / kg or crude protein extract 150mg / kg gastric lavage, once a day for 7 consecutive days, can significantly reduce the fibrinogen content in rabbit plasma, inhibit platelet adhesion, reduce the whole blood viscosity ratio and plasma viscosity ratio, and can reduce the hematocrit to a certain extent.
These experiments have shown that flies may exert the clinical effect of blood activation, stasis, rupture and menstruation by reducing the "stickiness, concentration, coagulation and aggregation" of blood.